Tag: African swine fever virus

Commercially available cell line rapidly detects African swine fever virus

Scientists from the U.S. Department of Agriculture’s (USDA) Agricultural Research Service (ARS) have identified a new way to detect the presence of live African swine fever virus (ASFV) that minimizes the need for samples from live animals and provides easier access to veterinary labs that need to diagnose the virus. They report in the journal […]

Virally vectored ASFV antigens protect pigs from developing severe disease

Researchers at The Pirbright Institute have developed a vectored vaccine, which uses a non-harmful virus (adenovirus prime and modified vaccinia Ankara boost) to deliver eight strategically selected genes from the African swine fever virus (ASFV) genome into pig cells. Once inside the cell, the genes produce viral proteins which primes the pig immune cells to […]

Genome-wide transcriptome study of African swine fever virus

Scientists from The Pirbright Institute and University College London (UCL) have mapped the expression of genes across the entire African swine fever virus (ASFV) genome, which has helped to establish their order of activation as well as uncovering new genes. In their study, published in the Journal of Virology, the researchers used next generation sequencing […]

ASFV in feed: study improves half-life estimates

A study by Kansas State University provides more accurate half-life measurements that confirm African swine fever virus (ASFV) can survive a simulated 30-day transoceanic voyage in contaminated plant-based feed and ingredients. Their findings are published in Emerging Infectious Diseases. The research team, headed by Megan Niederwerder, assistant professor of diagnostic medicine and pathobiology in the […]

Identification of African swine fever virus antigens for vaccine development

Scientists at The Pirbright Institute have identified African swine fever virus (ASFV) proteins that can induce cellular and humoral immune responses in pigs. Published in Frontiers in Immunology, the study shows that when some pigs were challenged with a virulent strain of ASFV after receiving a vaccine that included the identified proteins, the level of […]

Project aims to develop African swine fever antivirals

The Pirbright Institute has announced that it will partner with the Belgian biotechnology company ViroVet to develop the first antiviral drugs that act against African swine fever virus (ASFV). In the absence of a vaccine, antiviral drugs could provide an alternative control method which would help limit clinical signs in pigs and lower virus replication. […]

ASFV vaccine candidate tested in wild boar

An article published in Frontiers in Veterinary Science describes the experimental vaccination of wild boar against African swine fever virus (ASFV). Oral immunization of wild boar with a non-haemadsorbing, attenuated ASFV of genotype II conferred 92% protection against challenge with a virulent ASF virus isolate (Arm07). “African swine fever is of enormous concern to the […]

Survival of ASFV and other viral pathogens in feed

Researchers have found that African swine fever virus (ASFV) could survive in a simulated Trans-Atlantic feed shipment. The study, published in PLOS ONE, evaluated the survival of ASFV and other important viral pathogens of livestock in animal feed ingredients imported into the United States under simulated transboundary conditions. The viruses were selected based on global […]

Modified virus shows promise as an ASF vaccine

Researchers have found that deleting a gene of African swine fever virus (ASFV) reduces its ability to cause infection and protects against a strain of the virus that causes severe disease. In the study, published in the Journal of Virology, scientists at The Pirbright Institute deleted an ASFV gene that codes for a protein (DP148R) thought […]

Unique structure of ASFV enzyme may allow drug development

A DNA-copying protein from African swine fever virus (ASFV) has a unique structure that may offer a target for drugs, according to a study published in PLoS Biology by Yiqing Chen and colleagues at Fudan University in Shanghai, China. Viral replication depends in part on a polymerase enzyme, AsfvPolX, that repairs breaks in the DNA, […]