Tag: Foot-and-mouth disease virus

Preclinical transmission of Foot-and-mouth disease virus studied in pigs

Foot-and-mouth disease virus (FMDV) spreads much more aggressively in pigs than previous research suggests, according to a study by U.S. Department of Agriculture (USDA) scientists. The study, published in Scientific Reports, shows that pigs infected with FMDV were highly contagious to other pigs just 24 hours after infection – long before showing any clinical signs […]

Creating FMDV hybrids for better vaccines

In collaborative research led by The Pirbright Institute, scientists have generated a hybrid Foot-and-mouth disease virus (FMDV) with improved stability, which will increase its effectiveness when administered as a vaccine. They targeted the Southern African Territories (SAT) 2 serotype viruses, which are among the least stable of the seven different types of FMDV. Developing vaccines […]

Study traces FMDV escape from Indian subcontinent

The seven different serotypes of Foot-and-mouth disease virus (FMDV) can be split further into lineages which normally exist in specific geographical areas or ‘pools’. Over the past five years, the geographical range of a serotype O lineage, named Ind-2001, has dramatically expanded into many countries in Asia and North Africa. Pirbright Institute researchers from the […]

FMDV contagion in carrier cattle

Foot-and-mouth disease virus (FMDV) is believed to be one of the most contagious pathogens of animals in its acute form; however, there is still controversy over whether it is transmissible from asymptomatic, long-term carriers. Despite the lack of evidence for transmission by direct contact with FMDV carrier cattle, there is demonstrable contagion associated with these […]

Method developed to detect FMDV in the environment

Sampling the environment is an effective way to detect Foot-and-mouth disease virus (FMDV), according to a paper published in Applied and Environmental Microbiology. The sampling method, swabbing environmental surfaces where livestock are kept, can be easily performed and can detect viral genetic material that can persist in the environment well beyond the time when livestock […]

Two new genetic groups of Foot-and-mouth disease virus identified

Researchers from The Pirbright Institute have examined the genetic material of Foot-and-mouth disease virus (FMDV) samples collected from eastern and southern Africa, and discovered two novel virus groups. Their findings are published in the journal Viruses. FMD viruses are categorised into seven different serotypes, out of which serotypes O, A and Southern African Territories (SAT) […]

FMDV protein could be used for disease detection

Dr Stephen Berryman and Dr Toby Tuthill from The Pirbright Institute have collaborated with the MRC Laboratory of Molecular Biology and other research institutes to uncover a system used by foot-and-mouth disease virus (FMDV) to prevent antiviral signalling of infected cells. The discovery could allow scientists to detect animals that have been infected with FMDV […]

Foot and mouth disease: impact of preclinical diagnosis on farm-to-farm transmission

Preclinical detection of Foot-and-mouth disease virus (FMDV) during outbreaks has the potential to allow earlier culling of infected herds and thereby reduce transmission and aid the control of epidemics. During an outbreak of foot and mouth disease, current control and eradication methods rely on rapid clinical detection and the removal of infected herds. In a […]