Efforts to control PPRV should focus on herd management style, not age

A study in Tanzania explored the rate of Peste des petits ruminants virus (PPRV) infection across ages and livestock management styles of sheep and goats, as well as in cattle, which do not express symptoms but can be infected by the virus. The study, published in the journal Viruses, provides insight into how to target PPRV control efforts and builds on previous research highlighting the importance of livestock management style in transmission.

“Infection risk varies by age for many well-known diseases, and knowing this can allow us to target high-risk age groups with control efforts, like vaccination,” said Catherine Herzog, epidemiologist and graduate student in biology at the Center for Infectious Disease Dynamics at Pennsylvania State University (Penn State) and lead author of the paper. “Our study was designed to determine if age is a key risk factor of PPRV transmission so that we can better target vaccination campaigns to control this virus.”

PPRV is present in Africa, the Middle East, and Asia, where livestock keepers rely heavily on sheep and goats for their livelihood. In 2015, FAO and OIE launched a global campaign to eradicate PPRV by 2030. While an affordable vaccine exists, it is not always available in rural areas, and research can help direct efforts to get the vaccine to high-risk populations.

The researchers studied the rate at which animals became infected (the force of infection) among different ages and livestock management styles in Tanzania. The research showed that while the force of infection was not significantly related to an animal’s age, it was greater in animals from pastoral areas, where people rely almost solely on livestock, compared to agropastoral areas, where people rely on a mix of livestock and agriculture.

“Our results suggest that no particular age group bears the burden of infection,” said Herzog. “Sheep and goats have some protection from the virus when they are first born if their mother was vaccinated or had recovered from previous infection with the virus. Therefore, it may be most reasonable to target animals for vaccination when that maternal immunity wears off, though additional studies are needed to determine the timing of this biological process so vaccines are given at the correct time.”

“These findings align with our previous results that suggest that management style of livestock plays an important role in PPRV infection risk,” said Ottar Bjørnstad, Distinguished Professor of Entomology and Biology and J. Lloyd and Dorothy Foehr Huck Chair of Epidemiology at Penn State, and a member of the research team. “We plan to investigate how specific husbandry practices — herd size, herd age structure, contact rates among livestock and wildlife, and access to veterinary service — affect risk of transmission so that we can better target control efforts of PPRV, which is currently a priority for world-wide elimination.”

The researchers also found evidence of prior PPRV infection in cattle, which was much higher than previous reports. Co-author Brian Willett at the University of Glasgow determined that previous testing kits had a low sensitivity in cattle, and should thus be refined to improve future monitoring. In this study, when the researchers adjusted calculations for the sensitivity and specificity of tests, evidence of prior infection in cattle increased, doubling in the oldest age group.

“These results suggest that cattle may play a more important role in PPRV transmission than previously realized,” said Bjørnstad. “Because the goal is to eradicate the virus, we need to better understand the role of PPRV transmission among cattle and other species that may carry the disease even though they are not the primary hosts.”

In addition to Herzog, Bjørnstad, and Willett, the research team includes Isabella Cattadori, Vivek Kapur, and Peter Hudson at Penn State; Will de Glanville, Sarah Cleaveland at the University of Glasgow; Joram Buza at the Nelson Mandela African Institute of Science and Technology in Tanzania; and Emmanuel Swai at the Ministry of Livestock and Fisheries in Tanzania.

This research was supported by the Bill & Melinda Gates Foundation Program for Enhancing the Health and Productivity of Livestock, the Biological Sciences Research Council, the Department for International Development, the Economic and Social Research Council, the Medical Research Council, the Natural Environment Research Council and the Defense Science & Technology Laboratory, under the Zoonoses and Emerging Livestock Systems (ZELS) programme.

Article: Herzog, C.M., de Glanville W.A., Willett, B.J., Cattadori, I.M., Kapur, V., Hudson, P.J., Buza, J., Swai, E.S., Cleaveland, S., Bjørnstad, O.N. (2020). Identifying Age Cohorts Responsible for Peste Des Petits Ruminants Virus Transmission among Sheep, Goats, and Cattle in Northern Tanzania. Viruses 12(2) 186, doi: 10.3390/v12020186

[SOURCE: Penn State]