Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v13
Development of a novel Brucellosis attenuated vaccine allowing DIVA
Dependencies
Next steps
Rationally Attenuated Candidates
Research Question
- The development of a novel attenuated vaccine that gives better protection and/or improved safety than current vaccines and allows differentiation of infected and vaccinated animals
Research Gaps and Challenges
- Which strain of the various Brucella species to start with
Solution Routes
- Establishing the immune responses to genetically modifies Brucella organisms
- Challenge experiments involving animals vaccinated with candidate organisms
Dependencies
- The generation of GM organisms where the genes for selected virulence factors have been removed
Projects
What activities are planned or underway?
The epidemiology of Brucella melitensis in dairy herds in Israel and development of a risk‑based surveillance & control program
Planned Completion date 01/01/2024
Source Countries:
India
Development of Improved Diagnostic and Control Strategies for Brucellosis in Livestock and Wildlife
Planned Completion date 06/10/2026
Source Countries:
United States