Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v16
Development of a Brucella subunit vaccine
Dependencies
Next steps
Subunit Vaccines
Research Question
- The development of an effective subunit vaccine for use on its own or in combination with other Brucella vaccines in a prime-boost combination
Solution Routes
- Establishing the immune responses to the various subunits
- Challenge experiments involving animals vaccinated with subunit candidate vaccines that resulted in interesting immune responses.
- Establishing that there isn’t interference between the various antigens
Dependencies
- The availability of suitable adjuvants to stimulate strong cell-mediated immune responses
- Identifying expression systems that give correct Antigen conformation
Projects
What activities are planned or underway?
The epidemiology of Brucella melitensis in dairy herds in Israel and development of a risk‑based surveillance & control program
Planned Completion date 01/01/2024
Source Countries:
India
Development of Improved Diagnostic and Control Strategies for Brucellosis in Livestock and Wildlife
Planned Completion date 06/10/2026
Source Countries:
United States