Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v112
Establishing the identity of protective antigens of the various Brucella species
Dependencies
- 13 Identification of the Brucella virulence factors that contribute to disease pathology
- 14 To establish the identity of the immunomodulatory factors and stealth mechanisms operating in Brucella infections
- 15 Host Responses to Natural Infection
- 16 To identify protective mechanisms in Brucella-infected animals
- 16A Antibody Response
- 16B Cell Mediated Immunity
Next steps
Identity of Protective Antigens
Research Question
- The identity the Brucella components that the host needs to respond to to prevent and contain infection
Research Gaps and Challenges
- Differentiating protective antigens from other antigens that the host is responding to which may be assisting the bacterium evade the hosts’ responses at a particular stage of infection.
- Identifying common antigens across the various Brucella species
- Immunogenicity vs virulence
Solution Routes
- To identify the antigens that are responsible for protective cellular responses.
- The identity of the antigens that the host is generating Abs to and their role in protection (preventing and clearing infection).
- Identifying possible protective antigens in the Brucella genome, their expression and trial in challenge experiments
Dependencies
- Identity of protective mechanisms operating in immune hosts – the role of cell-mediated immune responses and Abs.
- The genome sequence of various virus isolates
Projects
What activities are planned or underway?
Estimates of disease burden caused by foodborne pathogens in contaminated dairy products in Rwanda.
Planned Completion date 06/04/2023
Source Countries:
Netherlands
An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania
Planned Completion date 14/07/2021
Source Countries:
Netherlands