African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap9
Adjuvant
Dependencies
- 10 Expression systems
- 12 Identity of protective antigens
- 8 Attenuated organisms
Next steps
- 4 Inactivated vaccines
- 4A Safety
- 4B Delivery route
- 4C Delivery platform
- 4D Safety
- 5, 6 DNA/RNA vaccines/Subunit vaccines
- 5, 6A Safety
- 5, 6B Delivery route
- 5, 6C Delivery platform
- 5, 6D Efficacy in challenge model
Adjuvant
Research Question
- Identifying suitable adjuvants that generate an optimal immune response to the various vaccine candidates, possibly resulting in sterile immunity
Research Gaps and Challenges
- Generate both a strong VN Ab and a CTC response
Solution Routes
- Immune response to antigens delivered on nanoparticles
- Immune response following inclusion of various adjuvants with the candidate vaccines
Dependencies
- Identity of protective antigens
Projects
What activities are planned or underway?
The impact of temperature on transmission of African swine fever in contaminated livestock vehicles
Planned Completion date 01/01/2023
Source Countries:
Netherlands
A Multi-Laboratory Comparison of Methods for Detection and Quantification of African Swine Fever Virus.
Planned Completion date 07/03/2022
Source Countries:
Netherlands