African swine fever
African swine fever
African swine fever is a highly contagious, viral disease of pigs caused by African swine fever virus (ASFV), a large complex DNA virus and the only member of family Asfarviridae, genus Asfivirus. The virus can become endemic in feral or wild suids, and transmission cycles between these animals and Ornithodoros ticks can complicate or prevent eradication. Isolates of the virus vary in virulence. There is currently no vaccine or treatment.
ASF has spread in domestic pig populations throughout most sub-Saharan African countries. Transcontinental spread first occurred to Europe (Spain and Portugal) in 1957 and 1960, and from there to other European countries, South America and the Caribbean. With the exception of Sardinia, the disease was eradicated from outside Africa in the mid-1990s. A second transcontinental spread to Georgia in the Caucasus began in 2007, with subsequent spread to neighbouring countries and further into Eastern Europe with the wild boar (Sus scrofa) involved in the spread. Currently, ASFV is present in the Trans-Caucasus, parts of the Russian Federation and neighbouring countries, including Ukraine, Poland, Latvia, Lithuania, Estonia and Moldova, as well as, Hungary, Czech Republic and Romania. In 2018 the disease occurred in Belgium and also for the first time in China. In 2019 it has been disecovered in several countries in SE Asia, and has had a significant effect on the Chinese pork industry.
STAR-IDAZ IRC working with the Global African Swine Fever Research Alliance (GARA) aims to coordinate research, establish and sustain global research partnerships that will generate scientific knowledge and generate road maps for the prevention, control and where possible eradication of African Swine Fever. The current state of ASF research is covered in the Annual state-of-the art report on animal health research on IRC priorities.
STAR-IDAZ helped organize the EU-China collaboration on pig disease research with a particular focus on African Swine Fever, Beijing, 12 March 2019.
- Current status and evolving approaches to African swine fever vaccine development.
- An Update on African Swine Fever Virology.
- African Swine Fever Epidemiology and Control
- Identification and Immunogenicity of African Swine Fever Virus Antigens
- Subunit Vaccine Approaches for African Swine Fever Virus
- Development of vaccines against African swine fever virus
- Gaps in African swine fever: Analysis and priorities.
- Immunization of Pigs by DNA Prime and Recombinant Vaccinia Virus Boost To Identify and Rank African Swine Fever Virus Immunogenic and Protective Proteins.
- Architecture of African swine fever virus and implications for viral assembly.
- African swine fever: Update on Eastern, Central and Southern Africa
- ASFV in feed: study improves half-life estimates
- Identification of African swine fever virus antigens for vaccine development
- Project aims to develop African swine fever antivirals
- More research on African swine fever is urgently needed: No cure, no vaccine and no treatment yet exists for this lethal pig disease
- Deadly African swine fever arrives in China, the world’s largest producer of pigs
- FAO warns African swine fever may spread in Asia
- Consortium to tackle African swine fever and lumpy skin disease