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Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines

Roadmap for development of a candidate vaccine for PRRSV

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Vaccine

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Dependencies

  • 4 Inactivated vaccines
  • 4A Safety
  • 4B Delivery route
  • 4C Delivery platform
  • 4D Efficacy in challenge model
  • 5 DNA/RNA vaccines
  • 5A Safety
  • 5B Delivery route
  • 5C Delivery platform
  • 5D Efficacy in challenge model
  • 6 Subunit vaccines
  • 6A Safety
  • 6B Delivery route
  • 6C Delivery platform
  • 6D Efficacy in challenge model
  • 7 Vectored vaccines
  • 7A Safety
  • 7B Delivery route
  • 7C Delivery platform
  • 7D Efficacy in challenge model
An improved multivalent PRRSV vaccine preventing disease, virus transmission and carrier state in vaccinated animals

Research Question

  • Protection against disease caused by the various virus strains
  • Sterile immunity
  • Prevent vaccine virus contributing to evolution of field isolates
  • Virus eradication from a herd

Research Gaps and Challenges

  • Cross-protection against the various isolates
  • Attenuated live viruses can contribute to virus evolution
  • Generation of both a CTC and VN response
  • The dominant immunogens may not be protective

Solution Routes

  • Establish protection levels with various candidate vaccine options, including priming with one vaccine and boosting with a different vaccine
  • Establish if pig genetics influences responses
  • Incorporate the candidate vaccine in a vaccine platform covering a number of diseases
  • The development of farm strain-specific vaccines (autologous vaccines)

Dependencies

  • Development of cross protective/multivalent killed vaccine
  • Development of a cross protective/multivalent vectored vaccine
  • Development of a subunit vaccine
  • Development of an attenuated vaccine that does not persist or is excreted

Projects

What activities are planned or underway?

Generating antibodies broadly neutralising porcine reproductive and respiratory syndrome virus (PRRSV)

Planned Completion date 31/12/2025

Source Countries:

DenmarkIconDenmark

Identification of interferon stimulated genes that control Toxoplasma in pig macrophages

Planned Completion date 01/03/2026

Source Countries:

United KingdomIconUnited Kingdom