Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines
Roadmap for development of a candidate vaccine for PRRSV
Download PRRSV Vaccine Roadmap7
Vectored vaccines
Development of a cross protective/multivalent vectored PRRSV vaccine
Research Question
- The development of an effective vaccine that gives broad cross-protection but doesn’t contribute to virus evolution
Research Gaps and Challenges
- Generating a strong protective immune response with CTCs and VN Abs
- Preventing the development of immune responses to the vector
Solution Routes
- Monitoring the immune response following immunisation with the various candidates involving single/combination of antigens
- Challenge experiments with the various vaccine candidates
- Development of vaccine platforms Identify most appropriate route of administration (parenteral/oral/nasal)
Dependencies
- Identifying a combination of antigens for expression by a vector or a common single Ag to which immune responses are normally suppressed
- Identifying suitable vector
Projects
What activities are planned or underway?
Generating antibodies broadly neutralising porcine reproductive and respiratory syndrome virus (PRRSV)
Planned Completion date 31/12/2025
Source Countries:
Denmark
Identification of interferon stimulated genes that control Toxoplasma in pig macrophages
Planned Completion date 01/03/2026
Source Countries:
United Kingdom