Home ‹ African Swine Fever ‹ [Attenuated organisms] The generation of rationally attenuated genetically modified ASF virus
African Swine Fever roadmap:
Vaccines

Roadmap for the development of a candidate vaccine for ASF

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8

Attenuated organisms

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Dependencies

Next steps

Attenuated organisms

Research Question

  • To generate organisms that are less virulent in terms of pathological changes that they cause and/or their ability to modulate the host’s immune responses – rationally
    attenuated vaccine

Research Gaps and Challenges

  • Ensure the organisms are stable and can be produced in cell
    culture
  • Ensure the organisms can still generate a protective response
  • Ensure the organisms give protection against heterologous challenge

Solution Routes

  • Identify ASFV genes involved in virulence and in evasion of the host’s immune response.
    Generate and characterise a range of rationally attenuated organisms
  • Immune response to the attenuated organisms

Dependencies

  • Identify virulence factors and their genes
  • Identify immunomodulators
  • Ensure ability to give cross protection against heterologous challenge

Projects

What activities are planned or underway?

The impact of temperature on transmission of African swine fever in contaminated livestock vehicles

Planned Completion date 01/01/2023

Source Countries:

NetherlandsIconNetherlands

A Multi-Laboratory Comparison of Methods for Detection and Quantification of African Swine Fever Virus.

Planned Completion date 07/03/2022

Source Countries:

NetherlandsIconNetherlands