African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF-Vaccine-Roadmap_Updated_Oct258
Attenuated organisms
Dependencies
Next steps
- 3 Rationally attenuated candidates
- 3A Safety
- 3B Delivery route
- 3C Delivery platform
- 3D Efficacy in challenge model
- 9 Adjuvant
Attenuated organisms
Research Question
- To generate organisms that are less virulent in terms of pathological changes that they cause and/or their ability to modulate the host’s immune responses – rationally
attenuated vaccine
Research Gaps and Challenges
- Ensure the organisms are stable and can be produced in cell
culture - Ensure the organisms can still generate a protective response
- Ensure the organisms give protection against heterologous challenge
- Ensure that the mechanism of attenuation is defined at a molecular level, and its stability is ensured through multiple gene modifications
Solution Routes
- Identify ASFV genes involved in virulence and in evasion of the host’s immune response.
Generate and characterise a range of rationally attenuated organisms - Immune response to the attenuated organisms
Dependencies
- Identify virulence factors and their genes
- Identify immunomodulators
- Ensure ability to give cross protection against heterologous challenge
Projects
What activities are planned or underway?
Vaccines, diagnosis and epidemiology for control and prevention of African swine fever (SE1520)
Planned Completion date 31/12/2028
Source Countries:
UK
Production of Master Seed Virus for Development of Vaccine Against African Swine Fever
Planned Completion date 31/08/2026
Source Countries:
United States