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Brucellosis roadmap:
Vaccines

Roadmap for development of a candidate vaccine for Brucella

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Development of a novel Brucellosis attenuated vaccine allowing DIVA

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Dependencies

Next steps

Rationally Attenuated Candidates

Research Question

  • The development of a novel attenuated vaccine that gives better protection and/or improved safety than current vaccines and allows differentiation of infected and vaccinated animals

Research Gaps and Challenges

  • Which strain of the various Brucella species to start with

Solution Routes

  • Establishing the immune responses to genetically modifies Brucella organisms
  • Challenge experiments involving animals vaccinated with candidate organisms

Dependencies

  • The generation of GM organisms where the genes for selected virulence factors have been removed

Projects

What activities are planned or underway?

Development of a plant expressed, protein-based subunit vaccine against Brucellosis

Planned Completion date 30/11/2029

Principal Investigator(s)

Source Countries:

South AfricaIconSouth Africa

An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania

Planned Completion date 14/07/2021

Source Countries:

NetherlandsIconNetherlands