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Brucellosis roadmap:
Vaccines

Roadmap for development of a candidate vaccine for Brucella

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Development of a Brucella subunit vaccine

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Dependencies

Next steps

Subunit Vaccines

Research Question

  • The development of an effective subunit vaccine for use on its own or in combination with other Brucella vaccines in a prime-boost combination

Solution Routes

  • Establishing the immune responses to the various subunits
  • Challenge experiments involving animals vaccinated with subunit candidate vaccines that resulted in interesting immune responses.
  • Establishing that there isn’t interference between the various antigens

Dependencies

  • The availability of suitable adjuvants to stimulate strong cell-mediated immune responses
  • Identifying expression systems that give correct Antigen conformation

Projects

What activities are planned or underway?

Development of a plant expressed, protein-based subunit vaccine against Brucellosis

Planned Completion date 30/11/2029

Principal Investigator(s)

Source Countries:

South AfricaIconSouth Africa

An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania

Planned Completion date 14/07/2021

Source Countries:

NetherlandsIconNetherlands