Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v19
Identifying suitable delivery systems for subunit vaccine candidates, killed bacteria and DNA vaccine candidates
Dependencies
Next steps
- 4 Development of a killed/inactivated Brucella vaccine
- 4A Safety
- 4B Delivery Route
- 4C Delivery Platform
- 4D Efficacy in Challenge Model
- 5 Development of a DNA vaccine for Brucellosis
- 5A Safety
- 5B Delivery Route
- 5C Delivery Platform
- 5D Efficacy in Challenge Model
- 6 Development of a Brucella subunit vaccine
- 6A Safety
- 6B Delivery Route
- 6C Delivery Route
- 6D Efficacy in Challenge Model
Adjuvant
Research Question
- Generation of an optimal immune response to the various sub-unit candidates, killed bacteria and DNA candidates
Solution Routes
- Immune response to antigens delivered on Nanoparticles
- Immune response following inclusion of various adjuvants with the candidate vaccines
- Molecular adjuvants for DNA candidates
Dependencies
- Identity of protective mechanism and antigens
Projects
What activities are planned or underway?
Development of a plant expressed, protein-based subunit vaccine against Brucellosis
Planned Completion date 30/11/2029
Principal Investigator(s)
Source Countries:
South Africa
An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania
Planned Completion date 14/07/2021
Source Countries:
Netherlands