Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v18
Rationally attenuated genetically modified Brucella organisms
Next steps
- 3 Development of a novel Brucellosis attenuated vaccine allowing DIVA
- 3A Safety
- 3B Delivery Route
- 3C Delivery Platform
- 3D Efficacy in Challenge Model
- 9 Identifying suitable delivery systems for subunit vaccine candidates, killed bacteria and DNA vaccine candidates
Attenuated Organisms
Research Question
- Rational attenuation of Brucella by removing virulence genes so that it protects against infection but doesn’t cause disease
Research Gaps and Challenges
- That the GM bacterium is stable and can be grown in culture
Solution Routes
- Removal of one or more virulence genes and establishing viability and virulence/safety and immunogenicity of the resulting organism
Dependencies
- Identity of virulence factors
- Identity of immunomodulatory factors in the bacterium
Projects
What activities are planned or underway?
The epidemiology of Brucella melitensis in dairy herds in Israel and development of a risk‑based surveillance & control program
Planned Completion date 01/01/2024
Source Countries:
India
Development of Improved Diagnostic and Control Strategies for Brucellosis in Livestock and Wildlife
Planned Completion date 06/10/2026
Source Countries:
United States