Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v113
Identification of the Brucella virulence factors that contribute to disease pathology
Dependencies
- 17 Host Pathogen interaction in Brucellosis infection
- 17A Entry
- 17B Replication
- 17C Persistence/Clearance
Next steps
Identity of Virulence Factor
Research Question
- Identifying and removal of the factors contributing to pathological changes are essential for generating rationally attenuated vaccines
Research Gaps and Challenges
- Immunogenicity may be linked to virulence
Solution Routes
- Generation of a range of knock-out bacteria where putative virulence factors have been removed and their use in experimental infections
Dependencies
- Improved understanding of Brucella – macrophage interaction – Brucella and macrophage gene expression in different in vivo environments (macrophages from naïve, immune and carrier hosts)
Projects
What activities are planned or underway?
The epidemiology of Brucella melitensis in dairy herds in Israel and development of a risk‑based surveillance & control program
Planned Completion date 01/01/2024
Source Countries:
India
Development of Improved Diagnostic and Control Strategies for Brucellosis in Livestock and Wildlife
Planned Completion date 06/10/2026
Source Countries:
United States