Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v113
Identification of the Brucella virulence factors that contribute to disease pathology
Dependencies
- 17 Host Pathogen interaction in Brucellosis infection
- 17A Entry
- 17B Replication
- 17C Persistence/Clearance
Next steps
Identity of Virulence Factor
Research Question
- Identifying and removal of the factors contributing to pathological changes are essential for generating rationally attenuated vaccines
Research Gaps and Challenges
- Immunogenicity may be linked to virulence
Solution Routes
- Generation of a range of knock-out bacteria where putative virulence factors have been removed and their use in experimental infections
Dependencies
- Improved understanding of Brucella – macrophage interaction – Brucella and macrophage gene expression in different in vivo environments (macrophages from naïve, immune and carrier hosts)
Projects
What activities are planned or underway?
Development of a plant expressed, protein-based subunit vaccine against Brucellosis
Planned Completion date 30/11/2029
Principal Investigator(s)
Source Countries:
South Africa
An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania
Planned Completion date 14/07/2021
Source Countries:
Netherlands