Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap10
Expression systems
Expression systems
Research Question
- Fast and cost feasible protein expression systems
Research Gaps and Challenges
- Other antigens/factors than HA that can improve vaccine effectiveness
- HA are not all created equal, some are poor immunogens
- Speed of expression system
- Cost
- Scale up-capacity
Solution Routes
- Re-engineering of existing systems
- Multi-omics or a system-based biological approach may improve the quality of the expressed protein, such as creating a molecule with a better glycosylation profile
- Identification of novel expression system
State Of the Art
- Current expression systems are mostly focused on HA
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States