Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap12
Identity of protective antigens
Dependencies
Next steps
Identity of protective antigens
Research Question
- To identify the viral antigens that give strongest protection
Research Gaps and Challenges
- Is it a humoral or cell mediated immune response that is required or both
- Select best antigen based on age / type of animal
Solution Routes
- Generation of a range of viral antigens and use them to study response to natural and experimental infections
- Antigenic analysis of H5 and H7 viruses to ensure good (neutralizing) matching with potential vaccines
- Neuraminidase can be important, but harder to measure and harder to get high enough immune response
- Knock out viruses
Dependencies
- Immune response to natural/experimental infections
Projects
What activities are planned or underway?
US-UK Collab: Avian influenza virus in cattle, a framework for forecasting transmission dynamics of zoonotic disease in livestock systems
Planned Completion date 31/01/2030
Source Countries:
United States
PARTNERSHIP:Harnessing Bovine Organoids to Advance HPAI Influenza A Virus Research
Planned Completion date 14/03/2029
Source Countries:
United States