Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap10
Expression systems
Expression systems
Research Question
- Fast and cost feasible protein expression systems
Research Gaps and Challenges
- Other antigens/factors than HA that can improve vaccine effectiveness
- HA are not all created equal, some are poor immunogens
- Speed of expression system
- Cost
- Scale up-capacity
Solution Routes
- Re-engineering of existing systems
- Multi-omics or a system-based biological approach may improve the quality of the expressed protein, such as creating a molecule with a better glycosylation profile
- Identification of novel expression system
State Of the Art
- Current expression systems are mostly focused on HA
Projects
What activities are planned or underway?
US-UK Collab: Avian influenza virus in cattle, a framework for forecasting transmission dynamics of zoonotic disease in livestock systems
Planned Completion date 31/01/2030
Source Countries:
United States
PARTNERSHIP:Harnessing Bovine Organoids to Advance HPAI Influenza A Virus Research
Planned Completion date 14/03/2029
Source Countries:
United States