Helminths (including anthelmintic resistance) roadmap:
Vaccines
Roadmap for nematode vaccine development
Download Nematode Vaccine Roadmap17
Host-pathogen interactions
Dependencies
Next steps
Host-parasite interactions
Research Question
How the host and parasite interact, allowing or inhibiting parasite establishment, feeding and reproduction
Research Gaps and Challenges
- Establishment of the neuroendocrine mechanisms of parasite-induced in-appetance.
Solution Routes
- Establish which parasite genes are being expressed at different stages of the life-cycle and their role in parasite feeding, establishment and reproduction.
- Establish the degree of genetic variation in parasite populations and the impact of these variations on the host-parasite interaction and implications for vaccination.
Dependencies
- Good quality accessible annotated parasite genome sequences.
- Model systems for each species and relevant co-infections.
- Reagents to dissect the immune responses (+/- protection)
State Of the Art
- Ostertagia/Teladorsagia/Trichuris influence protein digestion and utilisation.
- Adequate knowledge of many systems for single species infections, paucity of studies/data on co-infections (helminths + other pathogens)
Projects
What activities are planned or underway?
Single-nucleotide polymorphisms in the beta-tubulin gene and its relationship with treatment response to albendazole in human soil-transmitted helminths in Southern Mozambique
Planned Completion date 14/09/2022
Source Countries:
Netherlands
An integrated set of novel approaches to counter the emergence and proliferation of invasive and virulent soil-borne nematodes – Project part: Fostering nematode suppression in soils by cover crops and addition of biological antagonists in Organic Farming (NEM-EMERGE)
Planned Completion date 31/12/2027
Source Countries:
Denmark