Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap12
Identity of protective antigens
Dependencies
Next steps
Identity of protective antigens
Research Question
- To identify the viral antigens that give strongest protection
Research Gaps and Challenges
- Is it a humoral or cell mediated immune response that is required or both
- Select best antigen based on age / type of animal
Solution Routes
- Generation of a range of viral antigens and use them to study response to natural and experimental infections
- Antigenic analysis of H5 and H7 viruses to ensure good (neutralizing) matching with potential vaccines
- Neuraminidase can be important, but harder to measure and harder to get high enough immune response
- Knock out viruses
Dependencies
- Immune response to natural/experimental infections
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals
Planned Completion date 31/05/2026
Source Countries:
United States