Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v14
Development of a killed/inactivated Brucella vaccine
Dependencies
Next steps
Inactivated Vaccines
Research Question
- The development of an effective killed vaccine that can be used in pregnant animals.
Research Gaps and Challenges
- Having the protective response involving both Abs and CTC
Solution Routes
- Generation of a range of recombinant organisms expressing protective Antigens from a range of Brucella species.
- Monitoring the immune response following immunisation with the various candidates.
- Challenge experiments with the various vaccine candidates.
Dependencies
- Identifying a combination of antigens for expression by a GM strain of Brucella
- The availability of suitable adjuvants to stimulate strong CTC and Ab responses.
Projects
What activities are planned or underway?
The epidemiology of Brucella melitensis in dairy herds in Israel and development of a risk‑based surveillance & control program
Planned Completion date 01/01/2024
Source Countries:
India
Development of Improved Diagnostic and Control Strategies for Brucellosis in Livestock and Wildlife
Planned Completion date 06/10/2026
Source Countries:
United States