Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v14
Development of a killed/inactivated Brucella vaccine
Dependencies
Next steps
Inactivated Vaccines
Research Question
- The development of an effective killed vaccine that can be used in pregnant animals.
Research Gaps and Challenges
- Having the protective response involving both Abs and CTC
Solution Routes
- Generation of a range of recombinant organisms expressing protective Antigens from a range of Brucella species.
- Monitoring the immune response following immunisation with the various candidates.
- Challenge experiments with the various vaccine candidates.
Dependencies
- Identifying a combination of antigens for expression by a GM strain of Brucella
- The availability of suitable adjuvants to stimulate strong CTC and Ab responses.
Projects
What activities are planned or underway?
Development of a plant expressed, protein-based subunit vaccine against Brucellosis
Planned Completion date 30/11/2029
Principal Investigator(s)
Source Countries:
South Africa
An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania
Planned Completion date 14/07/2021
Source Countries:
Netherlands