African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF-Vaccine-Roadmap_Updated_Oct254
Inactivated vaccines
Inactivated vaccines
Research Question
- The development of an effective killed virus vaccine that provide protection and is safe
Research Gaps and Challenges
- Having it efficacious
- Cross protection
- Stimulating protective response involving both VN Abs and CTC
Solution Routes
- Selection of inactivated whole virus preparations
- Monitoring the immune response following immunisation with the various candidates.
- Challenge experiments with the various vaccine candidates
Dependencies
- Selection of the right strain, titre and preparation/inactivation to induce a protective immunity
- The availability of suitable adjuvants to stimulate strong CTC and VN-Ab responses
State Of the Art
- Attempts to vaccinate animals using infected cell extracts, supernatants of infected pig peripheral blood leukocytes, purified and inactivated virions, infected glutaraldehyde-fixed macrophages, or detergent-treated infected alveolar macrophages failed to induce protective immunity
Projects
What activities are planned or underway?
Vaccines, diagnosis and epidemiology for control and prevention of African swine fever (SE1520)
Planned Completion date 31/12/2028
Source Countries:
UK
Production of Master Seed Virus for Development of Vaccine Against African Swine Fever
Planned Completion date 31/08/2026
Source Countries:
United States