Home African Swine Fever [Naturally attenuated candidates] : Development of a “naturally” attenuated vaccine that doesn’t persist or is excreted
African Swine Fever roadmap:
Vaccines

Roadmap for the development of a candidate vaccine for ASF

Download ASF Vaccine Roadmap

2

Naturally attenuated candidates

Dependencies

  • 18 Challenge model

Next steps

Naturally attenuated candidates

Research Question

  • The development of a cross protective ASF vaccine by passage in tissue culture or a mutant low pathogenic wild type strain

Research Gaps and Challenges

  • Lack of cross protection among different isolates
  • Risk of reversion to virulence

Solution Routes

  • Perform passage in tissue culture to reduce virulence
  • Identify mutant low pathogenic wild strains

Dependencies

  • Identify strains that give greatest cross protection
  • Develop suitable cell lines for high titre propagation and licensing

State Of the Art

  • Experimentally, some level of homologous protection can be achieved by inoculation of pigs with low-virulence isolates obtained by passage in tissue culture or by deletion of genes involved in virulence, as well as low virulence isolates from the field
  • Challenge models have been evaluated and are available

Projects

What activities are planned or underway?

The impact of temperature on transmission of African swine fever in contaminated livestock vehicles

Planned Completion date 01/01/2023

Source Countries:

NetherlandsIconNetherlands