African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap2
Naturally attenuated candidates
Naturally attenuated candidates
Research Question
- The development of a cross protective ASF vaccine by passage in tissue culture or a mutant low pathogenic wild type strain
Research Gaps and Challenges
- Lack of cross protection among different isolates
- Risk of reversion to virulence
Solution Routes
- Perform passage in tissue culture to reduce virulence
- Identify mutant low pathogenic wild strains
Dependencies
- Identify strains that give greatest cross protection
- Develop suitable cell lines for high titre propagation and licensing
State Of the Art
- Experimentally, some level of homologous protection can be achieved by inoculation of pigs with low-virulence isolates obtained by passage in tissue culture or by deletion of genes involved in virulence, as well as low virulence isolates from the field
- Challenge models have been evaluated and are available
Projects
What activities are planned or underway?
The impact of temperature on transmission of African swine fever in contaminated livestock vehicles
Planned Completion date 01/01/2023
Source Countries:
Netherlands
A Multi-Laboratory Comparison of Methods for Detection and Quantification of African Swine Fever Virus.
Planned Completion date 07/03/2022
Source Countries:
Netherlands