Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap19
Pathogen genome
Next steps
Pathogen genome
Research Question
- Knowledge of pathogen genome
Research Gaps and Challenges
- Genome sequencing time and cost Bioinformatic analysis
- Ability to fully interpret virus sequences– and understand epistatic interactions between virulence markers on different segments
Solution Routes
- Increase the full genome sequencing of recent circulating influenza strains from different species
- Evaluation of whole genome sequencing platforms
- Rapid whole genome sequencing and automated analysis pipelines
- Improve sensitivity and purification methods for whole-genome sequencing
- Need to identify molecular marker promoting high spread in poultry due to an excellent adaptation to domestic birds (Galliformes in
particular) - Studies to understand the emergence of LPAIV to HPAIV
- AI/machine learning/modelling approaches to understand whole genome effects
- Include omics on virus cell interaction
Dependencies
- Increase bioinformatic capacity
- Identification of segments with increased pathogenic risk for veterinary public health and monitoring of those (see disease control strategy roadmap)
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals
Planned Completion date 31/05/2026
Source Countries:
United States