Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap19
Pathogen genome
Next steps
Pathogen genome
Research Question
- Knowledge of pathogen genome
Research Gaps and Challenges
- Genome sequencing time and cost Bioinformatic analysis
- Ability to fully interpret virus sequences– and understand epistatic interactions between virulence markers on different segments
Solution Routes
- Increase the full genome sequencing of recent circulating influenza strains from different species
- Evaluation of whole genome sequencing platforms
- Rapid whole genome sequencing and automated analysis pipelines
- Improve sensitivity and purification methods for whole-genome sequencing
- Need to identify molecular marker promoting high spread in poultry due to an excellent adaptation to domestic birds (Galliformes in
particular) - Studies to understand the emergence of LPAIV to HPAIV
- AI/machine learning/modelling approaches to understand whole genome effects
- Include omics on virus cell interaction
Dependencies
- Increase bioinformatic capacity
- Identification of segments with increased pathogenic risk for veterinary public health and monitoring of those (see disease control strategy roadmap)
Projects
What activities are planned or underway?
US-UK Collab: Avian influenza virus in cattle, a framework for forecasting transmission dynamics of zoonotic disease in livestock systems
Planned Completion date 31/01/2030
Source Countries:
United States
PARTNERSHIP:Harnessing Bovine Organoids to Advance HPAI Influenza A Virus Research
Planned Completion date 14/03/2029
Source Countries:
United States