Home ‹ African Swine Fever ‹ [Vector] Identifying suitable vector for the expression/delivery of protective ASFV antigens
African Swine Fever roadmap:
Vaccines

Roadmap for the development of a candidate vaccine for ASF

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11

Vector

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Dependencies

Next steps

  • 7 Vectored vaccines
  • 7A Safety
  • 7B Delivery route
  • 7C Delivery platform
  • 7D Efficacy in challenge model
Vector

Research Question

  • The identification of a suitable vector for the expression/delivery of protective ASFV antigens

Research Gaps and Challenges

  • Ensure the expression of the antigens to induce a protective immune response.
  • Identify the best vector among those that already went through the regulatory process.
  • Create stable genetically modified organisms expressing the desired ASFV antigens

Solution Routes

  • Generate genetically modified organisms (viruses or bacteria) expressing the protective antigens of different ASFV strains
  • Use recombinant vaccine strains containing individual ASFV gene/s as vectors
  • Use recombinant ASFV subunit vaccines using swinepox virus as vector
  • Incorporate molecular adjuvants (expressing CD40 ligand)

Dependencies

  • Identify the most appropriate antigens
  • Ensure sufficient expression level
  • Develop capacity to test the expression
  • Identify the most suitable delivery systems (e.g. oral for wild suids in Europe)
  • Identify vectors being suitable for one dose administration

Projects

What activities are planned or underway?

The impact of temperature on transmission of African swine fever in contaminated livestock vehicles

Planned Completion date 01/01/2023

Source Countries:

NetherlandsIconNetherlands

A Multi-Laboratory Comparison of Methods for Detection and Quantification of African Swine Fever Virus.

Planned Completion date 07/03/2022

Source Countries:

NetherlandsIconNetherlands