Home ‹ African Swine Fever ‹ [Vector] Identifying suitable vector for the expression/delivery of protective ASFV antigens
African Swine Fever roadmap:
Vaccines

Roadmap for the development of a candidate vaccine for ASF

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11

Vector

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Dependencies

Next steps

  • 7 Vectored vaccines
  • 7A Safety
  • 7B Delivery route
  • 7C Delivery platform
  • 7D Efficacy in challenge model
Vector

Research Question

  • The identification of a suitable vector for the expression/delivery of protective ASFV antigens

Research Gaps and Challenges

  • Ensure the expression of the antigens to induce a protective immune response.
  • Identify the best vector among those that already went through the regulatory process.
  • Create stable genetically modified organisms expressing the desired ASFV antigens

Solution Routes

  • Generate genetically modified organisms (viruses or bacteria) expressing the protective antigens of different ASFV strains
  • Use recombinant vaccine strains containing individual ASFV gene/s as vectors
  • Use recombinant ASFV subunit vaccines using swinepox virus as vector
  • Incorporate molecular adjuvants (expressing CD40 ligand)

Dependencies

  • Identify the most appropriate antigens
  • Ensure sufficient expression level
  • Develop capacity to test the expression
  • Identify the most suitable delivery systems (e.g. oral for wild suids in Europe)
  • Identify vectors being suitable for one dose administration

Projects

What activities are planned or underway?

African Swine Fever virus inactivation by feed additives in vitro

Planned Completion date 01/01/2022

Source Countries:

NetherlandsIconNetherlands

The incursion risk of African swine fever for the Netherlands by human-mediated routes

Planned Completion date 01/01/2022

Source Countries:

NetherlandsIconNetherlands