Tag: vaccine development

IVIS2022: 13th International Veterinary immunology Symposium, South Africa, 8-12 August 2022

The symposium is held every three years in association with the International Congress of Immunology and brings Industry, Government, and Academic specialists together to provide an update and overview of new, cutting-edge information in basic and applied veterinary immunology. Topics include protective immunity, vaccine strategies, and important disease targets in various animal species. The IVIS […]

Tetramer-based analysis of FMDV segments could improve vaccine effectiveness

Researchers from The Pirbright Institute have identified new parts of foot-and-mouth disease virus (FMDV) that stimulate an immune response. Their findings, reported in Immunology, could be used to inform the design of improved vaccines. They also discovered that T helper cells were present in cattle samples four years after the animals had been vaccinated, indicating […]

Veterinary Vaccinology Landscape Survey: Community Consultation

UKRI-BBSRC, on behalf of the veterinary vaccinology research funders and programme owners, are consulting the research community (including those in academia, funding agencies, industry and others) on the current veterinary vaccinology research and innovation needs, as well as the future perspectives. The overall purpose is to gain a better understanding of the priorities, gaps, and barriers […]

ASFV vaccine candidate produced in a continuous cell line

The U.S. Department of Agriculture’s Agricultural Research Service (ARS) has announced that an African swine fever virus (ASFV) vaccine candidate has been adapted to grow in a cell line, which means that those involved in vaccine production will no longer have to rely on live pigs and their fresh cells for vaccine production. “This opens […]

Infectious bronchitis virus: increasing vaccine heat resilience could improve performance

Studies from The Pirbright Institute and the University of Edinburgh’s Roslin Institute show that two vaccines against specific strains of infectious bronchitis virus (IBV) do not offer complete protection against a third strain, and that this may be partly down to the temperature range the vaccine virus can survive in. Commercial IBV vaccines are currently […]

IBDV VP4 protein dampens poultry immune response

Work carried out by scientists at The Pirbright Institute has revealed that differences in virulence between strains of Infectious bursal disease virus (IBDV) may be partly down to changes in the VP4 protein. Their findings, published in Frontiers in Cellular and Infection Microbiology, may help explain why very virulent (vv) strains cause high mortality rates […]

Virally vectored ASFV antigens protect pigs from developing severe disease

Researchers at The Pirbright Institute have developed a vectored vaccine, which uses a non-harmful virus (adenovirus prime and modified vaccinia Ankara boost) to deliver eight strategically selected genes from the African swine fever virus (ASFV) genome into pig cells. Once inside the cell, the genes produce viral proteins which primes the pig immune cells to […]

Genetic engineering speeds up poultry vaccine development

Scientists at The Pirbright Institute have used genetic engineering to develop a vaccine that protects birds against both Marek’s disease and avian influenza. They say the process is faster and more efficient compared to previous methods, which will allow poultry vaccine producers to rapidly update vaccine strains in order to keep up with virus evolution. […]

Modified BCG vaccine is compatible with a novel DIVA skin test

Scientists at the University of Surrey have developed a novel vaccine and complementary skin test to protect cattle against bovine tuberculosis. Publishing their findings in Scientific Reports, the researchers reveal they have created a vaccine that is compatible with a synthetic form of the tuberculin skin test (PPD). The BCG vaccine, which is currently used […]

Rift Valley fever vaccine found to be safe in pregnant animals

Researchers have shown that a simian adenovirus vectored vaccine, ChAdOx1 RVF, is effective at protecting pregnant sheep and goats from Rift Valley fever (RVF). They report their findings in npj Vaccines. Infection of livestock with Rift Valley fever virus (RVFV) results in high mortality and poor outcomes during pregnancy, including stillbirths, fetal malformations and abortions. […]