Tag: vaccine development

Mucosal vaccination protects mice against Brucella infection

Researchers at the University of Florida have demonstrated the efficacy of a novel vaccine for the protection of mice against Brucella melitensis infection. Their findings are published in Frontiers in Immunology. David Pascual and colleagues found that a live, attenuated vaccine delivered orally followed by an intranasal boost induced robust production of T cells in […]

Safety of ASFV vaccine candidate assessed

The U.S. Department of Agriculture’s Agricultural Research Service (ARS) has announced that a vaccine candidate for African Swine Fever (ASF) has passed an important safety test required for regulatory approval. The test is an important milestone as part of a series of safety studies. These new results, published in Viruses, show that USDA’s live attenuated […]

Platform technologies in veterinary vaccinology – review.

A review commissioned by STAR-IDAZ IRC on vaccine platforms has been published in the journal Vaccine (https://doi.org/10.1016/j.vaccine.2022.03.059). Vaccine platforms provide exciting opportunities to speed up the delivery of new vaccines particularly in the response to new and emerging diseases. The paper, Applications of platform technologies in veterinary vaccinology and the benefits for one health, was […]

Infectious bronchitis virus: reverse genetics system aids vaccine development

Researchers from The Pirbright Institute working to improve vaccines for infectious bronchitis virus (IBV) have developed a reverse genetics system, based on the pathogenic IBV strain M41, to identify genes which can be targeted for rational attenuation. Current vaccines for IBV are created by serial passage of virulent IBV field isolates through embryonated hens’ eggs. […]

New DIVA vaccine candidates against peste des petits ruminants virus

Two new vaccine candidates that could differentiate between vaccinated and infected animals and contribute to the goal of global eradication of peste des petits ruminants virus (PPRV) have been developed by researchers at The Pirbright Institute. In a study published in Viruses, researchers explored ways to create live attenuated DIVA (Differentiating Infected from Vaccinated Animals) […]

Research aims to improve enzootic abortion vaccines

A vaccine being developed against ovine enzootic abortion by scientists at the Moredun Research Institute has shown promising results in laboratory trials, being able to protect against abortion caused by Chlamydia abortus without the risk of causing infection in the animal. The results of the study are published in Vaccines. Ovine enzootic abortion is a […]

Improved poultry influenza vaccine provides rapid protection

A vaccine developed by researchers at The Pirbright Institute triggers a rapid immune response which protects chickens against signs of disease and reduces virus shedding. The researchers say the vaccine would also be easier and less costly to produce than the traditional influenza vaccines made in chicken eggs. Many poultry influenza vaccines protect birds from […]

Cocktail of recombinant proteins protects cattle against paratuberculosis

Scientists with the USDA’s Agricultural Research Service (ARS) have developed an experimental vaccine to protect cattle from infection with Mycobacterium avium subsp. paratuberculosis (MAP). Rather than use the cells of live but weakened or dead MAP, as has been done with past commercial vaccine formulations, ARS microbiologists Judy Stabel and John Bannantine set their sights […]

Tetramer-based analysis of FMDV segments could improve vaccine effectiveness

Researchers from The Pirbright Institute have identified new parts of foot-and-mouth disease virus (FMDV) that stimulate an immune response. Their findings, reported in Immunology, could be used to inform the design of improved vaccines. They also discovered that T helper cells were present in cattle samples four years after the animals had been vaccinated, indicating […]

Veterinary Vaccinology Landscape Survey: Community Consultation

UKRI-BBSRC, on behalf of the veterinary vaccinology research funders and programme owners, are consulting the research community (including those in academia, funding agencies, industry and others) on the current veterinary vaccinology research and innovation needs, as well as the future perspectives. The overall purpose is to gain a better understanding of the priorities, gaps, and barriers […]