Tag: vaccine development

Modified BCG vaccine is compatible with a novel DIVA skin test

Scientists at the University of Surrey have developed a novel vaccine and complementary skin test to protect cattle against bovine tuberculosis. Publishing their findings in Scientific Reports, the researchers reveal they have created a vaccine that is compatible with a synthetic form of the tuberculin skin test (PPD). The BCG vaccine, which is currently used […]

Rift Valley fever vaccine found to be safe in pregnant animals

Researchers have shown that a simian adenovirus vectored vaccine, ChAdOx1 RVF, is effective at protecting pregnant sheep and goats from Rift Valley fever (RVF). They report their findings in npj Vaccines. Infection of livestock with Rift Valley fever virus (RVFV) results in high mortality and poor outcomes during pregnancy, including stillbirths, fetal malformations and abortions. […]

Study of chicken gut cells may aid vaccine design

The colony-stimulating factor 1 receptor (CSF1R) has been shown to be expressed in the follicle-associated epithelium cells in the avian gut-associated lymphoid tissue. This was an unexpected finding as CSF1R is typically expressed in macrophages, not in epithelial cells. The results in studies with chicken cells pave the way for research looking to enhance the […]

Model predicts effectiveness of livestock vaccines

Scientists at The Roslin Institute have developed an epidemiological model to investigate the effectiveness of vaccines for preventing, mitigating or eliminating infectious diseases in livestock. When appropriately applied, even imperfect vaccines can prevent, eliminate or largely reduce the prevalence of viruses, the model shows. The goal of effective vaccination is not only to protect individuals […]

Identification of African swine fever virus antigens for vaccine development

Scientists at The Pirbright Institute have identified African swine fever virus (ASFV) proteins that can induce cellular and humoral immune responses in pigs. Published in Frontiers in Immunology, the study shows that when some pigs were challenged with a virulent strain of ASFV after receiving a vaccine that included the identified proteins, the level of […]