Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap13
Identity of virulence factors
Dependencies
Next steps
Identity of virulence factors
Research Question
- Molecular determinants of virulence and immune evasion in target
species
Research Gaps and Challenges
- Increase knowledge on virulence factors
Solution Routes
- Identify determinants of virulence, particularly in waterfowl, other
than HA cleavage site - Animals model to determine virulence markers
- Test in the model system not just rodent
- Study the role of internal genes in virulence in different species
Dependencies
- Identify high-reassortment strains could improve pandemic
preparedness or reveal new treatments (see disease control roadmap) - Viral, host and environment factors that influence the risk of acquiring an HA multibasic cleavage site
- Virus determinants ( other than MBCS ) of local replication and
potential systemic spread in target species
Projects
What activities are planned or underway?
planning for emerging infectious disease pandemics
Planned Completion date 26/07/2021
Source Countries:
Netherlands
Association of biosecurity and hygiene practices with avian influenza A/H5 and A/H9 virus infections in turkey farms.
Planned Completion date 14/03/2024
Source Countries:
Netherlands