Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap13
Identity of virulence factors
Dependencies
Next steps
Identity of virulence factors
Research Question
- Molecular determinants of virulence and immune evasion in target
species
Research Gaps and Challenges
- Increase knowledge on virulence factors
Solution Routes
- Identify determinants of virulence, particularly in waterfowl, other
than HA cleavage site - Animals model to determine virulence markers
- Test in the model system not just rodent
- Study the role of internal genes in virulence in different species
Dependencies
- Identify high-reassortment strains could improve pandemic
preparedness or reveal new treatments (see disease control roadmap) - Viral, host and environment factors that influence the risk of acquiring an HA multibasic cleavage site
- Virus determinants ( other than MBCS ) of local replication and
potential systemic spread in target species
Projects
What activities are planned or underway?
Risk and economic consequences of contagious animal disease introduction
Planned Completion date 18/10/2024
Source Countries:
Netherlands
Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta
Planned Completion date 21/10/2024
Source Countries:
Netherlands