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Roadmap for the development of candidate vaccines for influenza

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Identity of immunomodulators

Identity of immunomodulators

Research Question

  • Identity of main immunomodulators

Research Gaps and Challenges

  • Lack of knowledge of main roles of virus immunomodulators

Solution Routes

  • Standardized protocols for a set of cytokines to go with regular
    qPCR/titration assays

Dependencies

  • What else needs to be done before we can solve this need?
  • Better understanding of innate immunity in birds, swine, equine,
    canine
  • Role of prior exposure to other pathogens that might limit the host
    response to vaccination(e.g. Virus combinations)
  • Correlates of protection and effects of immunomodulators (some use just classical assays ie. HI)

Projects

What activities are planned or underway?

Impact of host age on viral and bacterial communities in a waterbird population.

Planned Completion date 01/11/2022

Source Countries:

NetherlandsIconNetherlands

planning for emerging infectious disease pandemics

Planned Completion date 26/07/2021

Source Countries:

NetherlandsIconNetherlands