Mycoplasmas including CBPP/CCPP roadmap:
Vaccines
Research roadmap for contagious bovine pleuropneumonia (CBPP) vaccine development
Download CBPP vaccine development roadmap final8
Attenuated organisms
Dependencies
Next steps
- 3 Rationally attenuated candidates
- 3A Safety
- 3B Delivery route
- 3C Delivery platform
- 3D Efficacy in challenge model
- 9 Adjuvant
Attenuated organisms
Research Question
- Live attenuated organism-based vaccines can provoke robust and long duration of immunity against disease.
- Overcomes the need to identify protective antigens but requires knowledge on how to attenuate Mmm.
Research Gaps and Challenges
- Monitoring production quality, consistent potency, free of other contaminating microorganisms
- Antibiotics cannot be used at the same time as the vaccine
- Lack of in vitro assays that correlate/associate with immunity to CBPP.
Solution Routes
- Develop a suite of methods to identify and down-select disease causing Mmm
Dependencies
- Standardize cattle breed specific laboratory challenge models that reproduce CBPP caused by natural infection or are acceptable surrogate models.
- Knowledge on the Mmm targets of host immune responses that contribute to disease and immunity.
- A list of Mmm candidate virulence/disease causing genes.
- A list of Mmm antigens that could serve as a candidate DIVA test.
- Rapid and accurate methods for Mmm genome manipulation at single and multiple loci.
- Methods to assess safety and efficacy of novel candidate vaccines.
Projects
What activities are planned or underway?
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject B (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject A (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark