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Influenza roadmap:
Vaccines

Roadmap for the development of candidate vaccines for influenza

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9

Adjuvant

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Dependencies

Next steps

  • 4 Inactivated vaccines
  • 4A Safety
  • 4B Delivery route
  • 4C Delivery platform
  • 4D Efficacy in challenge model
  • 5 DNA/RNA
  • 5A Safety
  • 5B Delivery route
  • 5C Delivery platform
  • 5D Efficacy in challenge model
  • 6 Subunit vaccines
  • 6A Safety
  • 6B Delivery route
  • 6C Delivery platform
  • 6D Efficacy in challenge model
Adjuvant

Research Question

  • New adjuvant stimulating durable immune response and no adverse reaction for the animal

Research Gaps and Challenges

  • Promote an appropriate immune response with reduced amount of
    antigen
  • Withdrawal time of adjuvant in livestock production systems
  • Adjuvants to improve/broad responses using vectors or attenuated
    organisms
  • Stability, safety and immunogenicity at a feasible cost
  • Adjuvants are primarily targeted to antibody response: harder to
    measure mucosal or cellular response and this limits field of application

Solution Routes

  • Better understanding of the mechanisms and immune – system – wide effects of new and existing adjuvants to enable rational design of improved vaccines with rapid onset of broadly – protective humoral, cellular and innate immunity
  • Development of vaccines/adjuvants to induce broad/universal clinical cross-protection
  • Mucosal adjuvants for IN application in swine/equine? and spray in
    poultry
  • Studies to establish the most suitable molecular adjuvants for nucleic acid-based vaccines that could be used in food producing species

Projects

What activities are planned or underway?

Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products

Planned Completion date 25/08/2029

Source Countries:

United StatesIconUnited States

Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment

Planned Completion date 31/08/2028

Source Countries:

United StatesIconUnited States