Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap15
Host responses to natural infection
Dependencies
Next steps
Host responses to natural infection
Research Question
- Better understanding of host response so that vaccines can be designed to address the challenges for multiple target species
Research Gaps and Challenges
- Role of prior infections to aid innate immune response or affect vaccines response e.g. subsequent vaccine uptake
- Effect of co – infection with different viruses and bacteria on AIV
transmission and pathogenesis - Role of pre – exposure to AIV on subsequent AIV infections
- Impact of NDV infection on AIV replication
- Knowledge on the duration of immunity of LP and HP in wild birds
- Some vaccines do not produce measurable correlates of protection
- Identify what is the main immune responses generated and against what
- Inhibition of immunity by other co- vaccines or co- infection (e.g. role of immunosuppressive diseases)
- What determines antigenic drift?
Solution Routes
- Immune response to IAV vaccine in young pigs co-infected with immunosuppressive viruses (PCV2 and/or PRRSV) lack of knowledge in horses too
- Characterization of the post-infectious adaptive immune response that determines protection from reinfection with homologous or heterologous strains
- Vaccine matching / role of intermediary immunity in protection and virus mutation
- Role of prior infections to aid innate immune response
- Dysregulation of the innate responses (or the lack of it ) in target species?
- Investigate immune mechanisms that impact the immunopathology
Dependencies
- Strategies to improve vaccine responses in ovo or in young animals, especially in the presence of maternal antibody (issue in both poultry and swine) (see control strategies roadmap)
- Develop strategies or technologies to induce earlier vaccine protection in ovo and in young poultry , e.g. rHVT (see control strategies roadmap)
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals
Planned Completion date 31/05/2026
Source Countries:
United States