Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap13
Identity of virulence factors
Dependencies
Next steps
Identity of virulence factors
Research Question
- Molecular determinants of virulence and immune evasion in target
species
Research Gaps and Challenges
- Increase knowledge on virulence factors
Solution Routes
- Identify determinants of virulence, particularly in waterfowl, other
than HA cleavage site - Animals model to determine virulence markers
- Test in the model system not just rodent
- Study the role of internal genes in virulence in different species
Dependencies
- Identify high-reassortment strains could improve pandemic
preparedness or reveal new treatments (see disease control roadmap) - Viral, host and environment factors that influence the risk of acquiring an HA multibasic cleavage site
- Virus determinants ( other than MBCS ) of local replication and
potential systemic spread in target species
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States