Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap16
Identity of mechanisms of protection
Dependencies
Next steps
Identity of mechanisms of protection
Research Question
- Understand host susceptibility and immune response in inter-and intra-host transmission
Research Gaps and Challenges
- Increase knowledge on host factors in natural hosts associated with resistance or susceptibility to influenza infection and several hosts (e.g. cell receptors, intracellular enzymes, innate immunity, etc. )
- Identify the contribution of the various arms of the immune response to protection – correlates of protection particularly in wild bird
- Knowledge on immunity levels required for re-infection of same or variants
Solution Routes
- Identification of B- and T-cell epitopes that provide best protection from inactivated and vectored vaccines
- Better understanding of response to attenuated pathogens – very limited knowledge in avian species
- Identification of conserved B- and T-cell epitopes within and between virus subtypes for targeting by vaccines
- Role of unregulated cytokine expression in production of vaccine associated enhanced respiratory disease of swine
- Immune correlates of vaccine-induced protection
- More reliable in vitro assays that can measure correlate of protection
Dependencies
- Development of rapid or reliable in vitro assays superior to HI /VN that also account for cellular and mucosal immune response and correlate with protection
Projects
What activities are planned or underway?
Risk and economic consequences of contagious animal disease introduction
Planned Completion date 18/10/2024
Source Countries:
Netherlands
Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta
Planned Completion date 21/10/2024
Source Countries:
Netherlands