Mycoplasmas including CBPP/CCPP roadmap:
Vaccines
Research roadmap for contagious bovine pleuropneumonia (CBPP) vaccine development
Download CBPP vaccine development roadmap final12
Identity of protective antigens
Dependencies
- 13 Identity of virulence factors
- 14 Identity of immunomodulators
- 15 Host responses to natural infection
- 16 Identity of mechanisms of protection
- 16A Antibody response
- 16B Cell mediated immunity
Next steps
Identity of protective antigens
Research Question
- Identify Mmm antigens that are the targets of innate and acquired protective immune responses
- Use protective antigens as experimental vaccines.
Research Gaps and Challenges
- Lack of assays to define candidate protective antigens.
Solution Routes
- Computational approaches to identify candidate genes.
- Develop assays to identify candidate antigens.
Dependencies
- Standardized cattle breed specific laboratory challenge models that reproduce CBPP caused by natural infection or are acceptable surrogates.
- A detailed antigen map of Mmm through different phases of CBPP using sera and cells from different tissues and stages of disease in different breeds of cattle.
State Of the Art
- Some experimental vaccine antigens have been identified.
Projects
What activities are planned or underway?
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject B (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject A (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark