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Helminths (including anthelmintic resistance) roadmap:
Vaccines

Roadmap for nematode vaccine development

Download Nematode Vaccine Roadmap
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5

DNA/RNA vaccines
  • ASafety
  • BDelivery route
  • CDelivery platform
  • DEfficacy in challenge model
"] --> 34987["

1

Vaccine
    "] 35007["

    6

    Subunit vaccine
    • ASafety
    • BDelivery route
    • CDelivery platform
    • DEfficacy in challenge model
    "] --> 34987["

    1

    Vaccine
      "] 35017["

      7

      Vectored vaccines
      • ASafety
      • BDelivery route
      • CDelivery platform
      • DEfficacy in challenge model
      "] --> 34987["

      1

      Vaccine
        "] 35022["

        9

        Adjuvant
          "] --> 34990["

          5

          DNA/RNA vaccines
          • ASafety
          • BDelivery route
          • CDelivery platform
          • DEfficacy in challenge model
          "] 35022["

          9

          Adjuvant
            "] --> 35007["

            6

            Subunit vaccine
            • ASafety
            • BDelivery route
            • CDelivery platform
            • DEfficacy in challenge model
            "] 35024["

            10

            Expression system
              "] --> 35022["

              9

              Adjuvant
                "] 35026["

                11

                Vector
                  "] --> 35017["

                  7

                  Vectored vaccines
                  • ASafety
                  • BDelivery route
                  • CDelivery platform
                  • DEfficacy in challenge model
                  "] 35028["

                  12

                  Identity of protective antigens
                    "] --> 35024["

                    10

                    Expression system
                      "] 35028["

                      12

                      Identity of protective antigens
                        "] --> 35022["

                        9

                        Adjuvant
                          "] 35028["

                          12

                          Identity of protective antigens
                            "] --> 35026["

                            11

                            Vector
                              "] 35047["

                              13

                              Identity of virulence factors
                                "] --> 35028["

                                12

                                Identity of protective antigens
                                  "] 35048["

                                  14

                                  Identity of immunomodulators
                                    "] --> 35028["

                                    12

                                    Identity of protective antigens
                                      "] 35051["

                                      15

                                      Host responses to natural infection
                                        "] --> 35028["

                                        12

                                        Identity of protective antigens
                                          "] 35051["

                                          15

                                          Host responses to natural infection
                                            "] --> 35054["

                                            16

                                            Identity of mechanisms of protection
                                            • AAntibody response
                                            • BCell-mediated immunity
                                            "] 35054["

                                            16

                                            Identity of mechanisms of protection
                                            • AAntibody response
                                            • BCell-mediated immunity
                                            "] --> 35028["

                                            12

                                            Identity of protective antigens
                                              "] 35061["

                                              17

                                              Host-pathogen interactions
                                              • AEntry
                                              • BReplication
                                              • CPersistence/ clearance
                                              "] --> 35051["

                                              15

                                              Host responses to natural infection
                                                "] 35061["

                                                17

                                                Host-pathogen interactions
                                                • AEntry
                                                • BReplication
                                                • CPersistence/ clearance
                                                "] --> 35048["

                                                14

                                                Identity of immunomodulators
                                                  "] 35061["

                                                  17

                                                  Host-pathogen interactions
                                                  • AEntry
                                                  • BReplication
                                                  • CPersistence/ clearance
                                                  "] --> 35047["

                                                  13

                                                  Identity of virulence factors
                                                    "] 35061["

                                                    17

                                                    Host-pathogen interactions
                                                    • AEntry
                                                    • BReplication
                                                    • CPersistence/ clearance
                                                    "] --> 35069["

                                                    18

                                                    Challenge model
                                                      "] 35073["

                                                      19

                                                      Pathogen genome
                                                        "] --> 35061["

                                                        17

                                                        Host-pathogen interactions
                                                        • AEntry
                                                        • BReplication
                                                        • CPersistence/ clearance
                                                        "] linkStyle default stroke-width:1px,stroke:#3bcaf2
                                                        Lead Summary Challenges and gap analysis
                                                        1 Vaccine Polyvalent vaccine giving long-lasting protection against infection by the predominant nematode species infecting livestock
                                                        5D Efficacy in challenge model
                                                        5C Delivery platform
                                                        5B Delivery route
                                                        5A Safety
                                                        5 DNA/RNA vaccines Development of nucleic acid-based vaccines
                                                        6D Efficacy in challenge model
                                                        6C Delivery platform
                                                        6B Delivery route
                                                        6A Safety
                                                        6 Subunit vaccine Development of a native anti-parasite vaccine
                                                        7D Efficacy in challenge model
                                                        7C Delivery platform
                                                        7B Delivery route
                                                        7A Safety
                                                        7 Vectored vaccines Development of a vectored vaccine
                                                        9 Adjuvant Conventional and molecular adjuvants
                                                        10 Expression system Expression system for subunit vaccine
                                                        11 Vector Vector identification for vectored vaccine
                                                        12 Identity of protective antigens Identity of protective antigens
                                                        13 Identity of virulence factors Identity of parasite virulence factors
                                                        14 Identity of immunomodulators Identity of immunomodulators
                                                        15 Host responses to natural infection Host response to natural infection
                                                        16B Cell-mediated immunity
                                                        16A Antibody response
                                                        16 Identity of mechanisms of protection Identity of mechanisms of protection
                                                        17C Persistence/ clearance
                                                        17B Replication
                                                        17A Entry
                                                        17 Host-pathogen interactions Host-parasite interactions
                                                        18 Challenge model Challenge model
                                                        19 Pathogen genome Pathogen genome